The Open Protein Structure Annotation Network
PDB Keyword


    Table of contents
    1. 1. Topsan Members
    2. 2. Summary
    3. 3. References

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    Topsan Members

    Tag pages as 'PF06228' to appear in this list.

    Name Annotation Author(s)


    Pfam family PFAM:PF06228 {Protein of unknown function (DUF1008) } with 77 members in NR database and additional 11 members in the metagenomic datasets is represented in Bacteria. The first structural representative solved (PDB Id: TOPSAN:2hqv) was subject to FATCAT structural similarity search that indicated similarity to SCOP (v. 1.73) domain SCOP:d2hq2a1 classified as Heme iron utilization protein-like, duplication fold. Profile-profile methods confirm remote homology between this family and superfamily of Heme iron utilization protein-like; fold of the same name. Based on sequence and structure analysis/ original paper one can hypothesize that this family is binding site for heme, while conserved in HemS and ChuS, is not conserved in AGR_C_4470p, suggesting that it probably has a different function




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