The Open Protein Structure Annotation Network
PDB Keyword


    Table of contents
    1. 1. Topsan Members
    2. 2. Summary

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    Topsan Members

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    Pfam family PFAM:PF05891 {Eukaryotic protein of unknown function (DUF858)} with 120 members in NR database and additional 8 members in the metagenomic datasets is represented in Eukaryota. The first structural representative solved (PDB Id: TOPSAN:1xtp) was subject to FATCAT structural similarity search that indicated similarity to SCOP (v. 1.73) domain SCOP:d1tw3a2 classified as S-adenosyl-L-methionine-dependent methyltransferase fold. Profile-profile methods confirm remote homology between this family and superfamily of S-adenosyl-L-methionine-dependent methyltransferases; fold of the same name. Based on remote homology confirmed by the structure, ligand one can hypothesize that this family is probably involved in transfer of methyl group




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