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The Open Protein Structure Annotation Network
PDB Keyword
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PF04672

    Table of contents
    1. 1. Topsan Members
    2. 2. Summary

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    Topsan Members

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    Name Annotation Author(s)
    2qe6
    The Tfu_2867 gene (PF04672, also known as DUF574) from Thermobifida fusca YX encodes the YP_290923 protein of unknown function. 2qe6 adopts a Rossman fold (2qe6-CATH). Pre-SCOP puts 2qe6 in the alpha... chrisx (3 edits)
    pascual (2 edits)

    Summary

    Pfam family PFAM:PF04672 {Protein of unknown function (DUF574)} with 142 members in NR database and additional 1 members in the metagenomic datasets is represented in Bacteria. The first structural representative solved (PDB Id: TOPSAN:2qe6) was subject to FATCAT structural similarity search that indicated similarity to SCOP (v. 1.73) domain SCOP:d1rjda_ classified as S-adenosyl-L-methionine-dependent methyltransferase fold. Profile-profile methods confirm remote homology between this family and superfamily of S-adenosyl-L-methionine-dependent methyltransferases; fold of the same name. Based on remote homology confirmed by the structure, ligand one can hypothesize that this family is probably involved in transfer of methyl group

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