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The Open Protein Structure Annotation Network
PDB Keyword
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PF04525

    Table of contents
    1. 1. Topsan Members
    2. 2. Summary

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    Topsan Members

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    Name Annotation Author(s)
    1zxu

    Summary

    Pfam family PFAM:PF04525 {Protein of unknown function (DUF567) } with 222 members in NR database and additional 3 members in the metagenomic datasets is represented in Archaea, Bacteria, and Eukaryota. The first structural representative solved (PDB Id: TOPSAN:1zxu) was subject to FATCAT structural similarity search that indicated similarity to SCOP (v. 1.73) domain SCOP:d1c8za_ classified as Tubby C-terminal domain-like fold. Profile-profile methods confirm remote homology between this family and superfamily of none; also first template for PF03803. Based on remote homology confirmed by the structure one can hypothesize that this family is probably involved in distribution of phospholipids, related to scramblases

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