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PDB Keyword
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PF04480

    Table of contents
    1. 1. Topsan Members
    2. 2. Summary

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    Resources
    Pfam ID: DUF559 PDB: 3hrl_A
    Solved by: MCSG Priority Score: 4.6
    Member of this family is in PDB.
    Member of this clan is in PDB.
    Co-occurence with annotated domain(s) (no restrictions on number of architectures).
    HMMER:
      # sequence matches: 768 # architectures: 36 # taxonomy ids:350
    FFAS:
      Top FFAS hit in PDB: "3hrlA, Endonuclease-Like Protein" Top FFAS hit in Pfam: "PF10881, Protein of unknown function (DUF2726) "
    GRDB:
      Top significant hit (PDB90): "1cw0A, hydrolase/dna ; crystal structure analysis of very short patch repair (vsr) endonuclease in complex with a duplex dna "
      Top significant hit (PFAM25U): "PF10881, Protein of unknown function (DUF2726)"
    CATH: CATH Domain E-value CATH Node
      3hrlA00 5.40E-37
      1vsrA00 8.90E-10 3.40.960.10
    FUNFAM (eval=0.0000024 ): HpaII very short patch repair endonuclease -like
    PUBSERVER:
      Publications(s) found: 576
      Publications(s) meeting filtering criteria: 14
    E.coli Annotations
    NCBI: 16129250 PORTECO PORAL: ycjD GeneExpDB: b1289

    Topsan Members

    Tag pages as 'PF04480' to appear in this list.

    No TOPSAN member(s) found.

    Summary

    This family belongs to the PD-(D/E)-XK clan which suggests a broad function of nuclease.

    GO Function GO:0004518 nuclease activity Evidence: Inferred from inclusion in PDDEXK clan in Pfam.

    Investigating the gene context of members of this family shows that the members of this family are often found within an operon that encodes a multisubunit enzyme complex.  For example it is found in the middle of operons encoding aminoacyl-tRNA synthetases or ribonucleotide reductase operons in various species.  We tentatively suggest that this protein may act as a homing endonuclease.

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    References

     

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