The Open Protein Structure Annotation Network
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    Table of contents
    1. 1. Topsan Members
    2. 2. Summary

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    Pfam ID: DUF480 PDB: 3bz6_A
    Solved by: MCSG Priority Score: 2.6
    Member of this family is in PDB.
    Co-occurence with annotated domain(s) (no restrictions on number of architectures).
      # sequence matches: 371 # architectures: 3 # taxonomy ids:215
      Top FFAS hit in PDB: "3bz6A, UPF0502 protein PSPTO_2686" No significant hits in Pfam.
      Top significant hit (PDB90): "2nr3A, structural genomics, unknown function ; structural genomics, the crystal structure of a conserved hypothetical protein from pseudomonas syringae pv. tomato str. dc3000 "
    CATH: CATH Domain E-value CATH Node
      3echA01 0.0096
      Publications(s) found: 382
      Publications(s) meeting filtering criteria: 2
    GeneSilico Metaserver: (Login and password: Jamboree)
    PDBBLAST: PDB: 3bz6_A SCOP: predicted a.4.5
    FFAS: PDB: 3bz6_A SCOP: predicted a.4.5
    MGENTHREADER: PDB: 3bz6_A SCOP: predicted a.4.5
    BLASTP: PDB: 3bz6_A SCOP: predicted a.4.5
    HHBLITS: PDB: 2nr3_A
    COMPASS: PDB: 3bz6_A SCOP: predicted a.4.5
    CSBLAST: PDB: 3bz6_A SCOP: predicted a.4.5
    HHSEARCH: PDB: 2nr3_A
    E.coli Annotations
    NCBI: 16129030 PORTECO PORAL: yceH GeneExpDB: b1067

    Topsan Members

    Tag pages as 'PF04337' to appear in this list.

    Name Annotation Author(s)


    Pfam family PFAM:PF04337 {Protein of unknown function, DUF480 } with 152 members in NR database and additional 52 members in the metagenomic datasets is represented in Bacteria. The first structural representative solved (PDB Id: TOPSAN:3bz6) was subject to FATCAT structural similarity search that indicated similarity to SCOP (v. 1.73) domain SCOP:d1sfxa_ classified as DNA/RNA-binding 3-helical bundle fold. (Note: additional/lacking secondary structure elements). Based on marginal prediction from FFAS confirmed by structural similarity one can argue that this family is remotely homologous to previously known structures from 'd1sfxa_' this fold. Based on fold and evidence of homology one can hypothesize that this family is probably binds nucleic acids




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