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PF04296

    Table of contents
    1. 1. Topsan Members
    2. 2. Summary
    3. 3. References

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    Resources
    Pfam ID: DUF448 PDB: 1g2r_A
    Solved by: MCSG Priority Score: 3.6
    Member of this family is in PDB.
    Co-occurence with annotated domain(s) (no restrictions on number of architectures).
    HMMER:
      # sequence matches: 1035 # architectures: 4 # taxonomy ids:758
    FFAS:
      Top FFAS hit in PDB: "1g2rA, HYPOTHETICAL CYTOSOLIC PROTEIN" No significant hits in Pfam.
    GRDB:
      Top significant hit (PDB90): "1g2rA, structural genomics, unknown function ; hypothetical cytosolic protein coded by gene from nusa/infb, ylxr homologue "
    CATH: CATH Domain E-value CATH Node
      1g2rA00 1.90E-29 3.30.1230.10
    PUBSERVER:
      Publications(s) found: 629
      Publications(s) meeting filtering criteria: 4
    GeneSilico Metaserver: (Login and password: Jamboree)
    PDBBLAST: PDB: 1g2r_A SCOP: d.192.1.1
    FFAS: PDB: 1g2r_A SCOP: d.192.1.1
    MGENTHREADER: PDB: 1g2r_A SCOP: d.192.1.1
    PRC: PDB: 1g2r_A SCOP: d.192.1.1
    SPARKS: PDB: 1g2r_A SCOP: d.192.1.1
    BLASTP: PDB: 1g2r_A SCOP: d.192.1.1
    HHBLITS: PDB: 1g2r_A SCOP: d.192.1.1
    COMPASS: PDB: 1g2r_A SCOP: d.192.1.1
    COMA: PDB: 1g2r_A SCOP: d.192.1.1
    CSBLAST: PDB: 1g2r_A SCOP: d.192.1.1
    HHSEARCH: PDB: 1g2r_A SCOP: d.192.1.1

    Topsan Members

    Tag pages as 'PF04296' to appear in this list.

    Name Annotation Author(s)
    1g2r

    Summary

    Pfam family

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    {Protein of unknown function (DUF448)} with 602 members in NR database and additional 314 members in the metagenomic datasets is represented in Bacteria. The first structural representative solved (PDB Id:
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    ) was subject to FATCAT structural similarity search that yielded no results, thus suggesting that it is a novel fold. Based on sequence and structure analysis/ original paper one can hypothesize that this family is it is proposed that YlxR is an RNA-binding protein.

    Genomic context suggest this protein could be related to translation as it can be often found in chromosomal clusters with translation factors (infB, rbfA). In 51 out of ~1500 cases, this domain is fused to the ribosomal protein domain (PF01248) indication it can be involved in translation.

    Reviews

    References

     

    No references found.

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