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    Table of contents
    1. 1. Topsan Members
    2. 2. Summary

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    Pfam ID: DUF447 PDB: 2iml_A
    Solved by: NYSGXRC Priority Score: 2.6
    Member of this family is in PDB.
    Member of this clan is in PDB.
      # sequence matches: 146 # architectures: 3 # taxonomy ids:118
      Top FFAS hit in PDB: "2nr4A, Conserved hypothetical protein" Top FFAS hit in Pfam: "PF01613, Flavin reductase like domain "
      Top significant hit (PDB90): "2nr4A, structural genomics, unknown function ; crystal structure of conserved fmn bound hypothetical protein from methanosarcina mazei "
      Top significant hit (PFAM25U): "PF01613, Flavin reductase like domain"
    CATH: CATH Domain E-value CATH Node
      3b5mC02 2.40E-13
      1wv4A00 0.0018
      2htiA00 0.0025
      Publications(s) found: 96
      Publications(s) meeting filtering criteria: 1
    GeneSilico Metaserver: (Login and password: Jamboree)
    PDBBLAST: PDB: 2nr4_A SCOP: b.45.1.4
    FFAS: PDB: 2nr4_A SCOP: b.45.1.4
    BLASTP: PDB: 2ptf_A SCOP: b.45.1.4
    HHBLITS: PDB: 3b5m_A
    COMPASS: PDB: 2iml_A SCOP: predicted b.45.1.1
    CSBLAST: PDB: 2nr4_A SCOP: b.45.1.4
    HHSEARCH: PDB: 2nr4_A SCOP: b.45.1.4

    Topsan Members

    Tag pages as 'PF04289' to appear in this list.

    Name Annotation Author(s)


    Pfam family PFAM:PF04289 {Protein of unknown function (DUF447) } with 96 members in NR database and additional 52 members in the metagenomic datasets is represented in Archaea, and Bacteria. The first structural representative solved (PDB Id: TOPSAN:2iml) was subject to FATCAT structural similarity search that indicated similarity to SCOP (v. 1.73) domain SCOP:d1i0ra_ classified as Split barrel-like fold. (Note: additional/lacking secondary structure elements). Based on marginal prediction from FFAS confirmed by structural similarity one can argue that this family is remotely homologous to previously known structures from 'd1i0ra_' this fold. Based on fold and evidence of homology, ligands one can hypothesize that this family is probably a flavoprotein




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