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PF04273

    Table of contents
    1. 1. Topsan Members
    2. 2. Summary

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    Resources
    Pfam ID: DUF442 PDB: 2f46_A
    Solved by: JCSG Priority Score: 3.6
    Member of this family is in PDB.
    Member of this clan is in PDB.
    Co-occurence with annotated domain(s) (no restrictions on number of architectures).
    HMMER:
      # sequence matches: 491 # architectures: 14 # taxonomy ids:277
    FFAS:
      Top FFAS hit in PDB: "2f46A, hypothetical protein" Top FFAS hit in Pfam: "PF03162, Tyrosine phosphatase family "
    GRDB:
      Top significant hit (PDB90): "2f46A, structural genomics, unknown function ; crystal structure of (7380613) from neisseria meningitidis fam18 at 1.41 a resolution "
      Top significant hit (PFAM25U): "PF03162, Tyrosine phosphatase family"
    CATH: CATH Domain E-value CATH Node
      2imgA00 0.0045 3.90.190.10
      1yn9C00 0.00017
      1tq1A00 0.0049 3.40.250.10
    FUNFAM (eval=0 ): Beta-lactamase hydrolase-like protein -like
    PUBSERVER:
      Publications(s) found: 269
      Publications(s) meeting filtering criteria: 5
    GeneSilico Metaserver: (Login and password: Jamboree)
    PDBBLAST: PDB: 2f46_A SCOP: predicted c.45.1.1
    FFAS: PDB: 3gxg_A SCOP: predicted c.45.1.1
    BLASTP: PDB: 2f46_A SCOP: predicted c.45.1.1
    HHBLITS: PDB: 2f46_A SCOP: predicted c.45.1.1
    COMPASS: PDB: 2f46_A SCOP: predicted c.45.1.1
    COMA: PDB: 2f46_A SCOP: predicted c.45.1.1
    CSBLAST: PDB: 1xi9_A SCOP: c.67.1.1 ECC: predicted 2.6.-.-
    HHSEARCH: PDB: 2f46_A SCOP: predicted c.45.1.1

    Topsan Members

    Tag pages as 'PF04273' to appear in this list.

    Name Annotation Author(s)
    2f46
    The gene NMA1982 from Neisseria meningitidis z2491 encodes the YP_002343251 protein, a  putative tyrosine phosphatase from the DUF442 family (PF04273).   The 2f46 structure belongs to the class of alp... chrisx (3 edits)
    pascual (2 edits)
    anton (1 edits)

    Summary

    Pfam family

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    {Putative phosphatase (DUF442) } with 398 members in NR database and additional 275 members in the metagenomic datasets is represented in Bacteria. The first structural representative solved (PDB Id:
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    ) was subject to FATCAT structural similarity search that indicated similarity to SCOP (v. 1.73) domain
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    classified as Phosphotyrosine protein - phosphatases II fold. Profile-profile methods confirm remote homology between this family and superfamily of (Phosphotyrosine protein) phosphatases II; fold of the same name. Based on remote homology confirmed by the structure one can hypothesize that this family is probably protein phosphatase.

    Reviews

    References

     

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