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PF04041

    Table of contents
    1. 1. Topsan Members
    2. 2. Summary

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    Resources
    Pfam ID: DUF377 PDB: 1vkd_A
    Solved by: JCSG Priority Score: 3.6
    Member of this family is in PDB.
    Member of this clan is in PDB.
    HMMER:
      # sequence matches: 778 # architectures: 13 # taxonomy ids:320
    FFAS:
      Top FFAS hit in PDB: "3tawA, Hypothetical glycoside hydrolase" Top FFAS hit in Pfam: "PF08950, Protein of unknown function (DUF1861) "
    GRDB:
      Top significant hit (PDB90): "1vkdA, structural genomics, unknown function ; crystal structure of hypothetical protein (tm1225) from thermotoga maritima at 2.10 a resolution "
      Top significant hit (PFAM25U): "PF04616, Glycosyl hydrolases family 43"
    CATH: CATH Domain E-value CATH Node
      1st8A01 0.0035
      1w0pA02 0.00065 2.120.10.10
      3k1uA00 0.0048 2.115.10.20
    PUBSERVER:
      Publications(s) found: 955
      Publications(s) meeting filtering criteria: 229
    GeneSilico Metaserver: (Login and password: Jamboree)
    PDBBLAST: PDB: 1vkd_A SCOP: b.67.2.4 ECC: predicted 3.2.-.-
    FFAS: PDB: 1vkd_A SCOP: b.67.2.4 ECC: predicted 3.2.-.-
    MGENTHREADER: PDB: 1vkd_A SCOP: b.67.2.4 ECC: predicted 3.2.-.-
    PRC: PDB: 2b4w_A SCOP: predicted b.67.2.5
    SPARKS: PDB: 1vkd_A SCOP: b.67.2.4 ECC: predicted 3.2.-.-
    BLASTP: PDB: 1vkd_A SCOP: b.67.2.4 ECC: predicted 3.2.-.-
    HHBLITS: PDB: 1vkd_A SCOP: b.67.2.4 ECC: predicted 3.2.-.-
    COMPASS: PDB: 1vkd_A SCOP: b.67.2.4 ECC: predicted 3.2.-.-
    CSBLAST: PDB: 1vkd_A SCOP: b.67.2.4 ECC: predicted 3.2.-.-
    HHSEARCH: PDB: 1vkd_A SCOP: b.67.2.4 ECC: predicted 3.2.-.-

    Topsan Members

    Tag pages as 'PF04041' to appear in this list.

    Name Annotation Author(s)
    1vkd
    The gene TM1225 from Thermotoga maritima encodes the NP_229030 protein from the DUF377 group (PF04041). The protein belongs to the glycosyl hydrolases 43 superfamily COG2152. The genomic neighborhood... anton (1 edits)
    pascual (1 edits)

    Summary

    Pfam family PFAM:PF04041 {Domain of unknown function (DUF377) } with 161 members in NR database and additional 74 members in the metagenomic datasets is represented in Archaea, Bacteria, and Eukaryota. The first structural representative solved (PDB Id: TOPSAN:1vkd) was subject to FATCAT structural similarity search that indicated similarity to SCOP (v. 1.73) domain SCOP:d1uypa2 classified as 5-bladed beta-propeller fold. Profile-profile methods confirm remote homology between this family and superfamily of Arabinanase/levansucrase/invertase; 5-bladed beta-propeller fold. Based on remote homology confirmed by the structure one can hypothesize that this family is probably involved in sugar binding or nucleotide hydrolysis

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