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PDB Keyword
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PF03928

    Table of contents
    1. 1. Topsan Members
    2. 2. Summary

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    Resources
    Pfam ID: DUF336 PDB: 2a2l_A
    Solved by: NYSGXRC Priority Score: 3.6
    Member of this family is in PDB.
    Co-occurence with annotated domain(s) (no restrictions on number of architectures).
    HMMER:
      # sequence matches: 1338 # architectures: 12 # taxonomy ids:570
    FFAS:
      Top FFAS hit in PDB: "2a2lA, unknown" Top FFAS hit in Pfam: "PF05651, Putative sugar diacid recognition "
    GRDB:
      Top significant hit (PDB90): "2a2lA, structural genomics, unknown function ; crystal structure of klebsiella pneumoniae hypothetical protein orfy, new york structural genomics consortium "
    CATH: CATH Domain E-value CATH Node
      2a2lA00 1.10E-38
    PUBSERVER:
      Publications(s) found: 589
      Publications(s) meeting filtering criteria: 35
    GeneSilico Metaserver: (Login and password: Jamboree)
    PDBBLAST: PDB: 2a2l_A SCOP: predicted d.110.9.1
    FFAS: PDB: 2a2l_A SCOP: predicted d.110.9.1
    MGENTHREADER: PDB: 2a2l_A SCOP: predicted d.110.9.1
    PRC: PDB: 2a2l_A SCOP: predicted d.110.9.1
    BLASTP: PDB: 2a2l_A SCOP: predicted d.110.9.1
    HHBLITS: PDB: 2a2l_A SCOP: predicted d.110.9.1
    COMPASS: PDB: 2a2l_A SCOP: predicted d.110.9.1
    CSBLAST: PDB: 2a2l_A SCOP: predicted d.110.9.1
    HHSEARCH: PDB: 2a2l_A SCOP: predicted d.110.9.1
    E.coli Annotations
    NCBI: 16130877 PORTECO PORAL: glcG GeneExpDB: b2977

    Topsan Members

    Tag pages as 'PF03928' to appear in this list.

    Name Annotation Author(s)
    2a2l

    Summary

    Pfam family PFAM:PF03928 {Domain of unknown function (DUF336) } with 826 members in NR database and additional 416 members in the metagenomic datasets is represented in Archaea, Bacteria, and Eukaryota. The first structural representative solved (PDB Id: TOPSAN:2a2l) was subject to FATCAT structural similarity search that indicated similarity to SCOP (v. 1.73) domain SCOP:d1j3wa_ classified as Profilin-like fold. Based on marginal prediction from FFAS confirmed by structural similarity one can argue that this family is remotely homologous to previously known structures from 'd1j3wa_' this fold. Based on remote homology confirmed by the structure one can hypothesize that this family is homologous to sensor proteins

    Streptomyces reticuli HbpS (UniProtKB:Q9RIM2) is a heme-binding protein that predominantly comprises this domain. The protein forms an octomer that interacts with a sensor kinase, SenS [PMID:19244623]. In vitro studies indicate that this domain has heme degradation activity.

    Reviews

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