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PF01949

    Table of contents
    1. 1. Topsan Members
    2. 2. Summary

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    Resources
    Pfam ID: DUF99 PDB: 2qh9_A
    Solved by: MCSG Priority Score: 1.6
    Member of this family is in PDB.
    HMMER:
      # sequence matches: 121 # architectures: 2 # taxonomy ids:103
    FFAS:
      Top FFAS hit in PDB: "2qh9A, UPF0215 protein AF_1433" Top FFAS hit in Pfam: "PF04493, Endonuclease V "
    GRDB:
      Top significant hit (PDB90): "2qh9A, structural genomics, unknown function ; the crystal structure of a protein of unknown function from archaeoglobus fulgidus dsm 4304 "
      Top significant hit (PFAM25U): "PF04493, Endonuclease V"
    CATH: CATH Domain E-value CATH Node
      2qh9A00 9.60E-54 3.30.2170.10
      2w36B00 0.00096
    PUBSERVER:
      Publications(s) found: 103
      Publications(s) meeting filtering criteria: 0
    GeneSilico Metaserver: (Login and password: Jamboree)
    PDBBLAST: PDB: 2qh9_A SCOP: predicted c.55.3.6
    FFAS: PDB: 2qh9_A SCOP: predicted c.55.3.6
    MGENTHREADER: PDB: 2qh9_A SCOP: predicted c.55.3.6
    BLASTP: PDB: 2qh9_A SCOP: predicted c.55.3.6
    HHBLITS: PDB: 2qh9_A SCOP: predicted c.55.3.6
    COMPASS: PDB: 2qh9_A SCOP: predicted c.55.3.6
    CSBLAST: PDB: 2qh9_A SCOP: predicted c.55.3.6
    HHSEARCH: PDB: 2qh9_A SCOP: predicted c.55.3.6

    Topsan Members

    Tag pages as 'PF01949' to appear in this list.

    Name Annotation Author(s)
    2qh9

    Summary

    Pfam family

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    {Protein of unknown function DUF99} with 52 members in NR database and additional 9 members in the metagenomic datasets is represented in Archaea, and Bacteria.

    The first structural representative solved (PDB Id:

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    ) was subject to FATCAT structural similarity search that indicated similarity to SCOP (v. 1.73) domain
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    classified as ribonuclease H-like motif fold and superfamily. A DALI search using 2qh9 as query returns hits with endonuclease-V 3ga2, 3goc and 2w35 (Z=13) [Ref], followed by the argonaute protein structures 3hk2, 3f73 and 2f8s (Z=11) [Ref]. A Blast search with 2qh9 sequence (AF1433) returns a hit (e-val=1e-38; 29% seq. id.) with the endonuclease-V entry YP_001737819. Analysis of the genomic context of 2qh9 (gene AF1433) reveals a weak functional link (0.675) with rpoM gene that codes for a DNA-directed RNA polymerase subunit M.

    Based on marginal prediction from FFAS confirmed by structural similarity, one can argue that this family is remotely homologous to other families with the ribonuclease fold.

    Reviews

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