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    Table of contents
    1. 1. Topsan Members
    2. 2. Summary

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    Pfam ID: DUF86 PDB: 1ylm_A
    Solved by: RSGI Priority Score: 4.6
    Member of this family is in PDB.
    Member of this clan is in PDB.
    Co-occurence with annotated domain(s) (no restrictions on number of architectures).
      # sequence matches: 1015 # architectures: 9 # taxonomy ids:396
      Top FFAS hit in PDB: "1ylmA, hypothetical protein BSU32300" Top FFAS hit in Pfam: "PF08780, Nucleotidyltransferase substrate binding protein like "
      Top significant hit (PDB90): "1ylmA, structural genomics, unknown function ; hypothetical cytosolic protein yute from bacillus subtilis "
      Top significant hit (PFAM25U): "PF08780, Nucleotidyltransferase substrate binding protein like"
    CATH: CATH Domain E-value CATH Node
      1wwpA00 1.00E-09
      1ylmA00 3.40E-30
      1jogA00 1.60E-08
      Publications(s) found: 183
      Publications(s) meeting filtering criteria: 2
    GeneSilico Metaserver: (Login and password: Jamboree)
    FFAS: PDB: 1ylm_A SCOP: predicted a.24.16.2
    PHYRE: PDB: 1ylm_A SCOP: predicted a.24.16.2
    MGENTHREADER: PDB: 1ylm_A SCOP: predicted a.24.16.2
    HHBLITS: PDB: 1wty_A SCOP: a.24.16.2
    COMPASS: PDB: 1ylm_A SCOP: predicted a.24.16.2
    COMA: PDB: 1ylm_A SCOP: predicted a.24.16.2
    HHSEARCH: PDB: 1ylm_A SCOP: predicted a.24.16.2

    Topsan Members

    Tag pages as 'PF01934' to appear in this list.

    Name Annotation Author(s)


    Pfam family PFAM:PF01934 {Protein of unknown function DUF86 } with 409 members in NR database and additional 169 members in the metagenomic datasets is represented in Archaea, and Bacteria.

    The first structural representative solved (PDB Id: TOPSAN:1ylm) was subject to FATCAT structural similarity search that indicated similarity to SCOP (v. 1.73) domain SCOP:d1wtya_ classified as Four-helical up-and-down bundle fold. Profile-profile methods confirm a remote homology between this family and the superfamily of nucleotidyltransferase substrate binding subunit/domain belonging to the four-helical up-and-down bundle fold. A DALI search with 1ylm as query only provides weak hits with the DUF103 protein 2hsb (Z=11) and the nucleotidyltransferase substrate binding-like protein 2ywa (Z=12).

    A BLAST search with the 1ylm protein sequence (YutE gene from B. subtilis) as query, provides a hit (e-value=1e-35 ; 52% seq. id.; 2% gaps) with the BselDRAFT_2929 gene annotated as cell division protein FtsA [Ref], although the source of this annotation is not clear and likely represents an annotation error.

    Accompaniment of mobile two-gene modules in the MNT-HEPN system. The element of bi-partite toxin-antitoxin system, may operate with nucleotidyltransferase subunit. 




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