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PF01904

    Table of contents
    1. 1. Topsan Members
    2. 2. Summary

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    Resources
    Pfam ID: DUF72 PDB: 1vpq_A
    Solved by: JCSG Priority Score: 2.6
    Member of this family is in PDB.
    HMMER:
      # sequence matches: 1303 # architectures: 5 # taxonomy ids:606
    FFAS:
      Top FFAS hit in PDB: "1vpqA, hypothetical protein TM1631" No significant hits in Pfam.
    GRDB:
      Top significant hit (PDB90): "1vpqA, structural genomics, unknown function ; crystal structure of hypothetical protein (tm1631) from thermotoga maritima at 2.20 a resolution "
    CATH: CATH Domain E-value CATH Node
      1vpqA00 7.80E-75 3.20.20.410
    PUBSERVER:
      Publications(s) found: 830
      Publications(s) meeting filtering criteria: 4
    GeneSilico Metaserver: (Login and password: Jamboree)
    PDBBLAST: PDB: 1vpy_A SCOP: c.1.32.1 ECC: predicted 2.8.-.-
    FFAS: PDB: 1vpq_A SCOP: c.1.32.1
    MGENTHREADER: PDB: 1vpq_A SCOP: c.1.32.1
    PRC: PDB: 1vpy_A SCOP: c.1.32.1 ECC: predicted 2.8.-.-
    SPARKS: PDB: 1vpq_A SCOP: c.1.32.1
    BLASTP: PDB: 1vpy_A SCOP: c.1.32.1 ECC: predicted 2.8.-.-
    HHBLITS: PDB: 1vpq_A SCOP: c.1.32.1
    COMPASS: PDB: 1vpq_A SCOP: c.1.32.1
    CSBLAST: PDB: 1vpy_A SCOP: c.1.32.1 ECC: predicted 2.8.-.-
    HHSEARCH: PDB: 1vpq_A SCOP: c.1.32.1
    E.coli Annotations
    NCBI: 16129821 PORTECO PORAL: yecE GeneExpDB: b1868

    Topsan Members

    Tag pages as 'PF01904' to appear in this list.

    Name Annotation Author(s)
    1vpq
    The TM1631 gene from Thermotoga maritima encodes a protein belonging to a large (~500 homologs, ~400 species) and widely distributed (archaea, eukaryotes, prokaryotes, viruses) family of domains of un... tinab (7 edits)
    pascual (6 edits)
    royk (2 edits)

    Summary

    Pfam family PFAM:PF01904 {Protein of unknown function DUF72 } with 478 members in NR database and additional 168 members in the metagenomic datasets is represented in Archaea, Bacteria, and Eukaryota. The first structural representative solved (PDB Id: TOPSAN:1vpq) was subject to FATCAT structural similarity search that indicated similarity to SCOP (v. 1.73) domain SCOP:d1q7za2 classified as TIM beta/alpha-barrel fold. Based on indirect marginal prediction from FFAS then confirmed by structural similarity, one can argue that this family is remotely homologous to other families with this fold.

    Summarizing 1vpq TOPSAN entry, DUF72 members could have a lyase/isomerase enzymatic activity related to DNA repair [Ref] [Ref].

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