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PF01861

    Table of contents
    1. 1. Topsan Members
    2. 2. Summary

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    Resources
    Pfam ID: DUF43 PDB: 2qm3_A
    Solved by: MCSG Priority Score: 2.6
    Member of this family is in PDB.
    Member of this clan is in PDB.
    HMMER:
      # sequence matches: 159 # architectures: 7 # taxonomy ids:119
    FFAS:
      Top FFAS hit in PDB: "2qm3A, Predicted methyltransferase" Top FFAS hit in Pfam: "PF05175, Methyltransferase small domain "
    GRDB:
      Top significant hit (PDB90): "2qm3A, transferase ; crystal structure of a predicted methyltransferase from pyrococcus furiosus "
      Top significant hit (PFAM25U): "PF10672, S-adenosylmethionine-dependent methyltransferase"
    CATH: CATH Domain E-value CATH Node
      1zq9B01 0.0064
      2ozvA01 0.0057 3.40.50.150
    FUNFAM (eval=0.00025 ): Ribosomal RNA small subunit methyltransferase D -like
    PUBSERVER:
      Publications(s) found: 1001
      Publications(s) meeting filtering criteria: 17
    GeneSilico Metaserver: (Login and password: Jamboree)
    FFAS: PDB: 2qm3_A SCOP: predicted c.66.1 ECC: predicted 2.7.-.-
    PHYRE: PDB: 2qm3_A SCOP: predicted c.66.1 ECC: predicted 2.7.-.-
    MGENTHREADER: PDB: 1sui_A SCOP: predicted c.66.1.1 ECC: 2.1.1.104
    HHBLITS: PDB: 2qm3_A SCOP: predicted c.66.1 ECC: predicted 2.7.-.-
    COMPASS: PDB: 2qm3_A SCOP: predicted c.66.1 ECC: predicted 2.7.-.-
    COMA: PDB: 2qm3_A SCOP: predicted c.66.1 ECC: predicted 2.7.-.-
    CSBLAST: PDB: 3c0k_A SCOP: predicted c.66.1 ECC: 2.1.1.-
    HHSEARCH: PDB: 2qm3_A SCOP: predicted c.66.1 ECC: predicted 2.7.-.-

    Topsan Members

    Tag pages as 'PF01861' to appear in this list.

    Name Annotation Author(s)
    2qm3

    Summary

    Pfam family PFAM:PF01861 {Protein of unknown function DUF43} with 30 members in NR database. The first structural representative solved (PDB Id: TOPSAN:2qm3) was subject to FATCAT structural similarity search that indicated similarity to SCOP (v. 1.73) domain SCOP:d1wy7a1 classified as S-adenosyl-L-methionine-dependent methyltransferase fold. Profile-profile methods confirm a remote homology between this family and the superfamily of S-adenosyl-L-methionine-dependent methyltransferase belonging to the fold with the same name. A search in DALI with 2qm3 as query, provides hits (Z=19-15) with methyltransferases like the PH1948 protein PDB:1wy7, TA1320 protein PDB:1ne2, and the putative O-methyl-transferase PDB:3dul and PDB:2hnk.

    Based on remote homology confirmed by the structure, one can hypothesize that this family is probably involved in methyl group transfer [Ref].

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