The Open Protein Structure Annotation Network
PDB Keyword

Bacteroides thetaiotaomicron

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    1. 1. Summary
    2. 2. Topsan Members



    Bacteroides thetaiotaomicron, Gram-negative anaerobe, is the first completely sequenced bacterium from the group of bacteria dominating a normal human distal intestinal microbiota, a vast community of indigenous microorganisms that colonize human gut and help to shape our biology. Its 4779-member proteome includes an elaborate apparatus for acquiring and hydrolyzing otherwise indigestible dietary polysaccharides and an associated environment-sensing system consisting of a large repertoire of extracytoplasmic function sigma factors and one- and two-component signal transduction systems. These and other expanded paralogous groups shed light on the molecular mechanisms underlying symbiotic host-bacterial relationships in our intestine. B. thetaiotaomicron genome also includes almost 2000 uncharacterized ORFs, many of which have been shown to be expressed in normal conditions (in the host). JCSG is now systematically targeting such proteins. 

    PSI centers, and in particular MCSG and JCSG already solved structures of over 100 proteins from Bacteroides thetaiotaomicron.

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