Welcome, guest The Open Protein Structure Annotation Network (TOPSAN) is a wiki designed to collect, share and distribute information about protein three-dimensional structures, and to advance it towards knowledge about functions and roles of these proteins in their respective organisms. TOPSAN will serve as a portal for the scientific community to learn about protein structures and also to contribute their expertise in annotating protein function. read more | . | Featured Annotation |  | 2h1q: The Dhaf4260 gene (uniprot: B8FUJ5) from Desulfitobacterium halfniense encodes a protein of unknown function (DUF364 (PF04016)) encountered in archaea and prokaryotes. The structure ... |
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TOPSAN - The Network News
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Error propagation
While annotating an orotidine 5′-phosphate decarboxylase from Thermotoga maritima (PDB id: 1vqt), I was surprised to come across an apparent paralog (PDB id: 2yyu) as Pfam showed a single gene for this enzyme in T. maritima. On closer inspection, it turned out the protein was actually an ortholog from Geobacillus kaustophilus but wrongly annotated in [...]
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Betting on Science
Here is one of those horror stories about how good science is severely cheapened by its unavailability to the science consuming public due to the inherent limitations of academic publishing. The author laments regarding some exciting new procedure, “It turns out that no one will have access to this method for a year or so.”
Ok, [...]
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